Search results for "BRAIN PLASTICITY"
showing 7 items of 7 documents
Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons
2014
Novel hypotheses suggest that antidepressants, such as the selective serotonin reuptake inhibitor fluoxetine, induce neuronal structural plasticity, resembling that of the juvenile brain, although the underlying mechanisms of this reopening of the critical periods still remain unclear. However, recent studies suggest that inhibitory networks play an important role in this structural plasticity induced by fluoxetine. For this reason we have analysed the effects of a chronic fluoxetine treatment in the hippocampus and medial prefrontal cortex (mPFC) of transgenic mice displaying eGFP labelled interneurons. We have found an increase in the expression of molecules related to critical period pla…
The effect of paired associative stimulation-induced long-term potentiation-like plasticity on visuomotor learning
2014
Aivojen hermostollisissa rakenteissa ja toiminnassa tapahtuu adaptaatiota motorisen oppimisen seurauksena. Eräs ehdotetuista malleista, johon muutokset voivat perustua on hermoliitoksen voimakkuuden pitkäaikainen tehostuminen eli pitkäkestoinen potentiaa-tio (LTP). Keinotekoisesti LTP:n kaltainen vaikutus voidaan tuottaa parillisella as-sosiatiivisella stimulaatiolla (PAS). Lisäksi tutkimustulokset osoittavat, että PAS voi parantaa tietyn tyyppistä motorista oppimista. Tämän tutkimuksen tarkoituksena on sel-vittää miten PAS:n tuottama LTP:n kaltainen plastisuus vaikuttaa visuomotorisen oppi-misen alkuvaiheeseen. Visuomotorinen oppimistehtävä suoritettiin kolme kertaa PAS:n jälkeen. Oppimist…
Toward a link between brain plasticity and satiety
2021
International audience
Cortical Reorganization after Rehabilitation in a Patient with Conduction Aphasia Using High-Density EEG
2020
Conduction aphasia is a language disorder occurred after a left-brain injury. It is characterized by fluent speech production, reading, writing and normal comprehension, while speech repetition is impaired. The aim of this study is to investigate the cortical responses, induced by language activities, in a sub-acute stroke patient affected by conduction aphasia before and after an intensive speech therapy training. The patient was examined by using High-Density Electroencephalogram (HD-EEG) examination, while was performing language tasks. the patient was evaluated at baseline and after two months after rehabilitative treatment. Our results showed that an intensive rehabilitative process, i…
Modulation of plasticity of the soleus area of the motor cortex using paired associative stimulation
2015
Paired associative stimulation (PAS) repeatedly combines single somatosensory nerve stimuli with single transcranial magnetic stimuli to induce bidirectional changes in the excitability of the cortical projections to the target muscle. PAS and motor training have been shown to share common neural mechanisms, suggesting that PAS tests functionally relevant neuronal circuits. While PAS has been used extensively to target the hand area of the motor cortex, few studies have targeted the leg area of the motor cortex. The optimal interstimulus inter- val (ISI) to induce plasticity in the cortical projections to lower limbs is still not well established. Thus, the first purpose of this thesis was …
Training the Motor Cortex by Observing the Actions of Others During Immobilization
2014
International audience; Limb immobilization and nonuse are well-known causes of corticomotor depression. While physical training can drive the recovery from nonuse-dependent corticomotor effects, it remains unclear if it is possible to gain access to motor cortex in alternative ways, such as through motor imagery (MI) or action observation (AO). Transcranial magnetic stimulation was used to study the excitability of the hand left motor cortex in normal subjects immediately before and after 10 h of right arm immobilization. During immobilization, subjects were requested either to imagine to act with their constrained limb or to observe hand actions performed by other individuals. A third gro…
Continuous neuronal integration in the cerebral cortex of rodents and humans
2021
La plasticidad neuronal es la capacidad del sistema nervioso para realizar cambios funcionales adaptativos, durante el desarrollo y la edad adulta. Se refiere a todo tipo de cambios que modifican la forma y estructura de las neuronas y de las células gliales del sistema nervioso central (SNC). Entre los diferentes niveles de plasticidad que ocurren en el cerebro adulto, la neurogénesis es un tipo de plasticidad cerebral, que implica la producción e incorporación continua de nuevas neuronas en las redes neuronales funcionales. En el cerebro de los mamíferos adultos, las nuevas neuronas se generan tradicionalmente en dos "nichos neurogénicos canónicos": la zona subventricular (SVZ) y la zona …